TITLE:
Animal Models of Hydrocephalus
AUTHORS:
Domenico L. Di Curzio
KEYWORDS:
Hydrocephalus, Animal Models, Kaolin, Mechanical, Genetic
JOURNAL NAME:
Open Journal of Modern Neurosurgery,
Vol.8 No.1,
December
27,
2017
ABSTRACT: Hydrocephalus is a neurological condition
characterized by altered cerebrospinal fluid (CSF) flow leading to an
accumulation of CSF inside the cranial vault. Neuropathogenesis associated with
hydrocephalus has been elucidated by pathological studies of human brains and
through experimental and genetic animal models. Experimental animal models have
been developed in numerous species using a variety of methods and agents to
induce hydrocephalus or through genetic mutations in rodents. Each of these
animal models has been described briefly in this review, along with the basic
strengths and weaknesses of each model. Although none of these models can fully
mimic the human condition, they each provide fundamental knowledge contributing
to understanding more about the pathogenesis of hydrocephalus and its
underlying causes.