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Demetriou, C., Abu-Amero, S., Thomas, A.C., Ishida, M., Aggarwal, R., Al-Olabi, L., Leon, L.J., Stafford, J.L., Syngelaki, A., Peebles, D., Nicolaides, K.H., Regan, L., Stanier, P. and Moore, G.E. (2014) Paternally Expressed, Imprinted Insulin-Like Growth Factor-2 in Chorionic Villi Correlates Significantly with Birth Weight. PLoS ONE, 9, e85454.
https://doi.org/10.1371/journal.pone.0085454

has been cited by the following article:

• TITLE: Rates and Risk Factors in Macrosomic Newborns among Non-Diabetic Parturients at Tiznit City, Morocco: A Case-Control Study

  AUTHORS: Amal Korrida

  KEYWORDS: Macrosomia, Nutritional Status, Risk Factors, Hormone Therapy, Pre-Pregnancy BMI, Caesarean Section, Obesity

  JOURNAL NAME: Open Access Library Journal, Vol.4 No.12, December 21, 2017

  ABSTRACT: Background: The present study was elaborated to assess the prevalence of high birth weight and its related risk factors for macrosomic infants among women in Southern Morocco. Methods: A case-control study was conducted on term singleton live-births, with no morbidity or malformation, of a sample of (n = 78) nulliparous and multiparous non-diabetic women delivering at Hassan I Provincial Hospital. Cases included neonates ≥ 4000 g, whereas controls comprised infants with birth weight between 2500 and 3999 g. Personal information was collected from pregnant women using a structured questionnaire, and through a review of their medical records. Associations between exposure and dependent variable (macrosomia) were calculated using linear and logistic regressions. Results: Macrosomia prevalence was 35.89%. Mean birth weight in cases was 4310.71 ± 246.96 g, and in controls 3076.00 ± 533.97 g. Maternal lifestyle behaviors, as well as sociodemographic factors were not associated with macrosomia, except for maternal age over 40 years (OR: 4.27, 95% CI: 0.98-18.68). Logistic regression model analysis indicated that macrosomia was strongly associated with hormone therapy (adjusted OR: 18.83, 95% CI: 1.54-214.51), followed by obesity/overweight history (adjusted OR: 7.94, 95% CI: 1.52-41.41), and pre-pregnancy BMI ≥ 25 Kg/m2 for pooled overweight and obesity factor (adjusted OR: 5.24, 95% CI: 1.54-17.82). Conclusion: Pre-pregnancy BMI > 25 kg/m2, pre-existing overweight/ obesity, and hormone therapy should be considered as independent risk factors for fetal macrosomia and require more attention from health professionals.