Article citationsMore>>

Banda, M., Speyer, C.L., Semma, S.N., Osuala, K.O., Kounalakis, N., Torres Torres, K.E., Barnard, N.J., Kim, H.J., Sloane, B.F., Miller, F.R., Goydos, J.S. and Gorski, D.H. (2014) Metabotropic Glutamate Receptor-1 Contributes to Progression in Triple Negative Breast Cancer. PLoS ONE, 9, e81126.
https://doi.org/10.1371/journal.pone.0081126

has been cited by the following article:

• TITLE: Cytotoxicity Study of Gold Nanoparticles on the Basal-Like Triple-Negative HCC-1937 Breast Cancer Cell Line

  AUTHORS: Christophe Massard, Clémence Dubois, Vincent Raspal, Pierre Daumar, Yves Sibaud, Emmanuelle Mounetou, Mahchid Bamdad, Oscar Komla Awitor

  KEYWORDS: Breast Cancer, “Basal-Like” Triple Negative, HCC-1937, Gold Nanoparticles, Cytotoxicity

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.9 No.1, December 18, 2017

  ABSTRACT: The Triple Negative “Basal-like” breast cancer (TNBL) tumours have a high proliferative capacity and develop a resistance phenotype associated with metastases. However, the management of TNBL carcinomas is still not standardized. Among the promising trails, gold nanoparticles could be a relevant tool for the development of a targeted treatment for this breast cancer subtype in monotherapy, associated and/or conjugated with other drugs. In this work, we report the cytotoxicity impact of gold nanoparticles wrapped in Poly-Ethylene Glycol (PEG) on the TNBL HCC-1937 breast cancer cell line. PEG-coated gold nanoparticles (PEG-Au NPs) were synthesized by a two-step method using a reduction process followed by a post-functionalization called PEGylation. PEG-Au NPs were characterized using transmission electron microscopy and X-ray diffraction. The gold content of the samples was determined using atomic absorption spectrometer. The cytotoxicity tests were performed using Sulforhodamine B survival test and resazurin viability test. PEG-Au NPs impact analysis on HCC1937 TNBL cell line showed a clear toxic action of type dose dependent and at long term. These PEGylated gold nanoparticles present a promising tool for the development of tumor-specific radiosensitizing vectors, with or without the association of other treatment strategies.