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Abadi, A.H., Ibrahim, T.M., Abouzid, K.M., Lehmann, J., Tinsley, H.N., Gary, B.D. andPiazza, G.A. (2009) Design, Synthesis and Biological Evaluation of Novel Pyridine Derivatives as Anticancer Agents and Phosphodiesterase 3 Inhibitors. Bioorganic & Medicinal Chemistry, 17, 5974-5982.
https://doi.org/10.1016/j.bmc.2009.06.063

has been cited by the following article:

• TITLE: Green Synthesis of Novel 5-Arylazo-2-[(2S, 3S, 4R, 5R)-3, 4, 5-Trihydroxy-6-(Hydroxymethyl) Tetrahydro-2H-Pyran-2-Yloxy]-4, 6-Dimethyl 3-Nicotinonitrile

  AUTHORS: Magda H. Abdellattif, Mohamed Mohamed Helmy Arief, Adel A. H. Abdel-Rahman, Abdel-Aleem H. Abdel Aleem, Abdel Moneam Farag Eissa

  KEYWORDS: Green Chemistry, Green Protocol, Pyridones, Fluroazo Compounds, Microwave

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.7 No.4, December 15, 2017

  ABSTRACT: Introduction: Pyridone derivatives played important roles in the last decade to approach many and different functionalities, especially as antitumor, antibacterial, anti-fungal, and many of pharmacological activities. Methodology: Novel compounds of 5-Arylazo-2-[(substituted)-3, 4, 5-trihydroxy-6-(hydroxymethyl) tetrahydro-2H-pyran-2-yloxy]-4, 6-dimethylnicotinonitrile, (3a-e), generally called (fluroarylazopyridine glucosides) were synthesised via green protocol, microwave. Results: The compounds were investigated by (IR, 1HNMR, 13CNMR and mass spectrometry). Where some of pharmacological activities like antibacterial and antifungal studies had been investigated and characterized. It was found that 3a-d had characterized by high activities as antibacterial and antifungal. Where microwave synthetic methods were more efficient, gave higher products quantity, and more saving for time requirement and for using of much more solvents.