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Groenikaki, A.A., Lagunin, A.A., Hadjipavlou-Litina, D.I., Eleftheriou, P.T., Filimonov, D.A., Poroikov, V.V., Alam, I. and Saxena, A.K. (2008) Computer-Aided Discovery of Anti-Inflammatory Thiazolidinones with Dual Cyclooxygenase/Lipoxygenase Inhibition. Journal of Medicinal Chemistry, 51, 1601-1609.
https://doi.org/10.1021/jm701496h

has been cited by the following article:

• TITLE: Fatty Acids in Heterocyclic Synthesis. Part XVII: Synthesis of Non Ionic Surfactants Containing Piperidine, Piperazine, Imidazole Based on Thiadiazole and Microbiological Activities Evaluation

  AUTHORS: Abdelmotaal Abdelmajeid, Mahasen Saad Amine, Reda Ali Hassan

  KEYWORDS: 2-Aminothiadiazole, Imidazole, Thiazole, Stearic Acid, Thiazolidine, Propylene Oxide, Nonionic Surfactant, Antimicrobial Activity

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.7 No.4, December 15, 2017

  ABSTRACT: A series of novel scaffolds Thiadiazolyl Piperidine, Thiadiazolyl Piperazine, thiadiazolidine, Thiadiazolyl thiazole and Thiadiazolyl-imidazole-Thione were synthesized from cheap, available and biologically active stearic acid. 2-amino-5-heptadecyl 1,3,4-thiadiazole reacts with chloroacetyl chloride and produced 2-choloro-N-(5-heptadecyl-1,3,4-Thiadiazole-2-yl) acetamide. Which allowed to react with Piperidine, Piperazine, urea and/or Thiourea and Potassium thiocyanate, and the latest scaffolds have been synthesized, respectively, and the structures of these compounds were established by elemental analysis, MS, IR and 1H-NMR spectral data. The antimicrobial activities of the synthesized compounds were evaluated in-vitro against strains of gram +ve, gram -ve bacteria and fungi. Nonionic surfactant were obtained by addition of different moles of propylene oxide (3,5,7 mole) to the synthesized compounds bearing an active hydrogen. Physico-chemical and surface properties as well as biodegradability of the synthesized non-ionic surfactants were evaluated.