TITLE:
Treatment of Recurrent Aphthous Stomatitis by 100% Topical Pumpkin Seed Oil
AUTHORS:
Khalifa E. Sharquie, Adil A. Noaimi, Tuqa M. Latif
KEYWORDS:
Recurrent Aphthous Stomatitis, Pumpkin Seed Oil, Therapy
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.7 No.4,
December
15,
2017
ABSTRACT: Background: Recurrent aphthous stomatitis (RAS) is a major oral
health problem, where its etiopathogenesis is not well understood. Accordingly,
its therapy whether topical or systemic can induce clearance, but
the relapse rate is high. Objective: To use 100% topical pumpkin seed
oil in RAS as it has many actions as anti-inflammatory and antioxidant effects. Patients and Methods: This single, blind, clinical, therapeutic trial was
conducted in the Department of Dermatology-Baghdad Teaching Hospital, Baghdad, Iraq,
during February 2015-August 2016. Twenty-five patients with RAS were included in this work. After full
history and clinical examination, the clinical diagnosis was established. Oral
clinical manifestation index score (OCMI) was carried out before, during and
after stopping therapy to assess the different parameters of this score. 100% Topical
pumpkin seed oil was given two times daily
for 3 months during which short term assessment for each patient was done by
using OCMI before, after 4 days and after 8 days of therapy in addition to
assessing the mean size of largest diameter of ulcers in each visit to evaluate
the therapeutic efficacy of the therapy, while long term assessment of the OCMI
was done every month for 3 months after starting of the therapy to evaluate the
prophylactic effect of the therapy. After 3 months, pumpkin seed oil was
stopped and assessment of OCMI was done monthly for another 3 months to
evaluate the remission action of pumpkin seed oil. Results: Twenty-five
patients were included in this study: 15
(60%) males and 10 (40%) females. While
their ages ranged from 9 - 60 (27.48 ± 11.97) years. The
mean of OCMI before pumpkin seed oil therapy was ranged from 9 - 15 (12.96 ± 1.42), while after the therapy the mean started to decline to lower level within
4 days of therapy and was statistically significant (p Conclusion: Pumpkin seed oil had an
effective therapeutic and prophylactic action against RAS, in addition, it
induced remission for at least 3 months after stopping therapy. No local or systemic
side effects were observed during the course of therapy.