TITLE:
Two Flavones from Acanthospermum hispidum DC and Their Antibacterial Activity
AUTHORS:
Theresa I. Edewor, Abass A. Olajire
KEYWORDS:
Acanthospermum hispidum DC, Flavonoids, Antibacterial, Spectroscopy
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.1 No.3,
September
28,
2011
ABSTRACT: Two new flavones, namely 5,7,2’,5’-tetrahydroxy-3,4’-dimethoxyflavone and 5’-acetoxy-5,7,2’-trihydroxy-3, 4’-dimethoxyflavone were successfuly isolated from the leaves of Acanthospermum hispidum DC and identified by UV-Vis, IR, 1H-NMR and EI-MS techniques. Both compounds exhibited antibacterial activity against Salmonella typii, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis, Bacillus subtilis, Pseudomonas aeruginosa and Shigella dysenteriae with minimum inhibition concentration (MIC) ranging from 0.001 - 0.20 but was inactive against Escherichia coli, Corybacterium pyogenes and Proteus vulgaris.