TITLE:
Phase Transfer Catalysis of Henry and Darzens Reactions
AUTHORS:
Layla Mhamdi, Hafedh Bohli, Younes Moussaoui, Ridha ben Salem
KEYWORDS:
Darzens, Henry, Phase Transfer Catalysis, Mechanism
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.1 No.3,
September
28,
2011
ABSTRACT: We describe in this work the influence of the addition of phase transfer catalyst in heterogeneous medium liquid/liquid on the output of the reactions of Darzens and Henry. It proves that the reaction of Darzens is favoured in the presence of low base such as K2CO3 and Et3N. Phase transfer catalysis is an efficient activation method in Darzens and Henry reactions. Thus, the Ethylene Diammonium Diacetate (EDD) has a comparable catalytic activity has that of quaternary ammonium salts in the reaction of Darzens.