TITLE:
The Effectiveness of Intraoperative Frozen Section Analysis of Safety Margins in Breast Conserving Surgery and the Role of Surgeon in Decreasing the Rate of Positive Margins
AUTHORS:
Omar Farouk, Ahmed Senbel, Mosab Shetiwy, Essam Attia, Ahmed Abdallah, Osama El-Damshety, Ashraf Khater, Sameh Roshdy, Amr Abouzid, Amr Hossam, Islam H. Metwally, Omar Hamdy, Amir M. Zaid, Mahmoud Abdelaziz, Mohamed Elmetwally, Adel Fathi, Emad-Eldeen Hamed, Khaled Abdel Wahab, Wagdi El-Kashef, Mohamed Hafez, Khaled Zalata, Mohamed Hegazy, Adel Denewer
KEYWORDS:
Breast Conserving Surgery, Intraoperative Frozen Section Analysis, Safety Margins, Breast
JOURNAL NAME:
Surgical Science,
Vol.8 No.12,
December
8,
2017
ABSTRACT: Introduction: Nowadays the more accepted surgical option for treating early breast cancer is breast conserving surgery. The main challenge in this type of surgery is to get free safety margins without need of second surgical operation, so many breast surgeons have started to depend on intraoperative frozen sections to ensure free safety margins. Aim of work: To assess our policy that we prefer to depend on intraoperative frozen section analysis to get free safety margin in breast conserving surgery from the 1st surgery, and its oncologic outcome. Patients and Methods: This is a retrospective study conducted in Oncology Center—Mansoura University (OCMU), where the data of 219 patients with breast cancer, who were managed by breast conserving surgery with intraoperative frozen section analysis of the safety margins, was analyzed. Results: The intraoperative frozen section analysis of safety margin was negative from the start in 183 (83.6%) patients, while it was positive in 36 patients (16.4%). Intraoperative decision of margin re-excision was applied for 29 patients (13.2%) in order to reach negative margin, modified radical mastectomy was offered for 4 patients (1.8%), while nipple sparing mastectomy with immediate breast reconstruction using latissimus dorsi flap was offered for 3 patients (1.4%). The postoperative paraffin results were typical with intraoperative frozen section analysis results in 216 patients (98.6%) and different results were obtained in only 3 patients (1.4%) who were managed by modified radical mastectomy in a second operation. Only 4 patients had local recurrence (1.8%) during the period of follow-up duration which was ranged from 1 to 86 months with mean ± SD (22.3 ± 14.1). Conclusion: The intraoperative frozen section analysis of safety margins in breast conserving surgery has very high-rate typical results with the paraffin section analysis and it is very helpful in decreasing the rate of second surgical operation in cases of infiltrated margins. It should be used routinely in all cases of breast conserving surgery.