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A. Imramovsky, S. Polanc, J. Vinsova, M. Kocevar, J. Jampitek, Z. Reckova and J. A. Kaustova, “A New Modification of Anti-Tubercular Active Molecules,” Bioor- ganic & Medicinal Chemistry, Vol. 15, No. 7, 2007, pp. 2551-2559. doi:10.1016/j.bmc.2007.01.051

has been cited by the following article:

• TITLE: Synthesis, Characterization and Antibacterial Activity of Biologically Important Vanillin Related Hydrazone Derivatives

  AUTHORS: Thiyagarajan Govindasami, Anjana Pandey, Nithya Palanivelu, Ashutosh Pandey

  KEYWORDS: Antibiotics, Fractional Crystallization, Hydrazones, Coupling Reaction

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.1 No.3, September 28, 2011

  ABSTRACT: Hydrazone derivatives of vanillin are found to possess anti-bacterial activities. Based on higher bio-activity of hydrazones, new hydrazone derivatives were synthesized from Piperdine-4-carboxylicacid methyl ester (1). The compounds 1-pyrimidine-2-yl piperidine-4-carboxylicacid(4-hydroxy-3-methoxy benzylidine)-hy- drazide (10), 1-pyrimidine-2-yl piperidine-4-carboxylicacid (3,4-dimethoxy benzylidine) hydrazide (11), 1-pyrimidine-2-yl piperidine-4-carboxylicacid(4-butoxy-3-methoxy benzylidine)-hydrazide (12), 1-pyr- imidine-2-yl piperidine-4-carboxylicacid(3-methoxy-4(2-methoxy ethoxy) benzylidine)-hydrazide (13) were synthesized, purified and characterized by 1HNMR, 13CNMR, LCMS, FT-IR and HPLC techniques. The synthesized hydrazone derivatives were further checked for anti-bacterial activities by paper disc diffusion method against Pseudomonas aeruginosa and Staphylococcus aureus bacterial strains.