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P. C. Lima, L. M. Lima, K. C. Silva, P. H. Leda, A. L. P. Miranda, C. A. M. Fraga, and E. J. Barreiro, “Synthesis and Analgesic Activity of Novel N-Acylarylhydrazones and Isosters, Derived from Natural Safrole,” European Journal of Medicinal Chemistry, Vol. 35, No. 2, 2000, pp. 187-203. doi:10.1016/S0223-5234(00)00120-3

has been cited by the following article:

• TITLE: Synthesis, Characterization and Antibacterial Activity of Biologically Important Vanillin Related Hydrazone Derivatives

  AUTHORS: Thiyagarajan Govindasami, Anjana Pandey, Nithya Palanivelu, Ashutosh Pandey

  KEYWORDS: Antibiotics, Fractional Crystallization, Hydrazones, Coupling Reaction

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.1 No.3, September 28, 2011

  ABSTRACT: Hydrazone derivatives of vanillin are found to possess anti-bacterial activities. Based on higher bio-activity of hydrazones, new hydrazone derivatives were synthesized from Piperdine-4-carboxylicacid methyl ester (1). The compounds 1-pyrimidine-2-yl piperidine-4-carboxylicacid(4-hydroxy-3-methoxy benzylidine)-hy- drazide (10), 1-pyrimidine-2-yl piperidine-4-carboxylicacid (3,4-dimethoxy benzylidine) hydrazide (11), 1-pyrimidine-2-yl piperidine-4-carboxylicacid(4-butoxy-3-methoxy benzylidine)-hydrazide (12), 1-pyr- imidine-2-yl piperidine-4-carboxylicacid(3-methoxy-4(2-methoxy ethoxy) benzylidine)-hydrazide (13) were synthesized, purified and characterized by 1HNMR, 13CNMR, LCMS, FT-IR and HPLC techniques. The synthesized hydrazone derivatives were further checked for anti-bacterial activities by paper disc diffusion method against Pseudomonas aeruginosa and Staphylococcus aureus bacterial strains.