TITLE:
Electrokinetics of Temperature for Development and Treatment of Effusions
AUTHORS:
Oliver Szasz, Gyula Peter Szigeti, Attila Marcell Szasz
KEYWORDS:
Effusion, Ascites, Edema, Modulated Electro-Hyperthermia, mEHT
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.8 No.11,
November
29,
2017
ABSTRACT: Introduction: Hyperthermia is a complementary therapy in oncology having various pros and
contras for its application. Ascites, pleural effusion, edema and other
electrolyte accumulations are frequently excluded from the treatability of the
patients with heating locally or systemically. The special gathering of electrolytes
is sometimes contraindicated, at times not mentioned in the clinical protocols.
However, it is certainly challenging in the oncology where micro and macro
edemas, as well as larger electrolyte accumulations (e.g. ascites, pleural
effusion), are very frequent. Methods: Excluding patients with accumulation of free electrolytes limits the
applications of hyperthermia. To find a solution we are studying the
microvasculature and fluid dynamism together with the electric field effects,
including the injury currents. The hyperthermia method which we investigate is
the modulated electro-hyperthermia (mEHT). We use the Starling’s equation and
the injury current in the frame of non-equilibrium
thermodynamics and in connection with the biologically closed electric
circuits. Results: It is shown that mEHT, unlike the conventional hyperthermia, is applicable for patients
who have edema and other free-electrolytes in
the volume which is targeted. The heterogeneous heating (unlike the homogeneous, isothermal conventional hyperthermia)
promotes the development of tumor-specific
immune actions, and so has less adverse-effects, and longer survival time for patients in advanced, metastatic
cancers too. Conclusion: mEHT is well
applicable in cases of ascites, pleural effusion, edema and other electrolyte accumulations when a patient is treated in
complex (complementary) oncological therapy.