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Conte, E., Federici, A. and Zbilut, J.P. (2009) A New Method Based on Fractal Variance Function for Analysis and Quantification of Sympathetic and Vagal Activity in Variability of R-R Time Series in ECG Signals. Chaos, Solitons & Fractals, 41, 1416-1426.

has been cited by the following article:

• TITLE: The Transcutaneous Vagus Nerve Stimulation Output of the NuCalm Device of Solace Lifesciences Is Found to Be a Multifractal and Therefore It Is Indicated in the Treatment of Heart Rate Variability in the Dysfunction of Autonomic Nervous System in Anxiety, Depression and Stress

  AUTHORS: Sergio Conte, Fang Wang, Nicoletta Sala, Francesco Losito Casciaro, Franco Orsucci, Giuseppe Serafini, Ferda Kaleagasioglu, Leonardo Mendolicchio, Rich Norman, Elio Conte

  KEYWORDS: Depression, Anxiety, Stress, Transcutaneous Vagus Nerve Stimulation, Neuromodulation, Heart Rate Variablity, Multifractals

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.7 No.11, November 21, 2017

  ABSTRACT: We have investigated the Nu Calm Transcutaneous Vagus Nerve Stimulation device of the NuCalm Solace Lifesciences founding that it gives a multifractal output. A diminishing fractal/multifractal HRV is consistently reported in literature as related to a serious Autonomic Nervous System (ANS) dysfunction that of course we observe in several psychological and psychiatric disorders. Therefore, we suggest the investigators to apply such a device in subjects affected from anxiety, depression and stress using the method of inducing tVNS stimulation.