TITLE:
Biomaterial Surface Can Modify HUVEC Morphology and Inflammatory Response by Regulating MicroRNA Expression
AUTHORS:
Shuangying Gu, Baoxiang Tian, Weicong Chen, Yue Zhou
KEYWORDS:
HUVEC, Vascular Inflammation, MicroRNAs
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.5 No.12,
November
21,
2017
ABSTRACT: Vascular inflammation is an important process which contributes to the pathogenesis of many cardiovascular diseases, such as atherosclerosis. MicroRNAs (miRNAs) have been revealed as novel regulators of vascular inflammation. Prior researches had shown that alterations in gene expression of human umbilical vein endothelial cells (HUVECs) associated with topo-graphic cues. Here, we showed that poly (dimethyl siloxane) (PDMS) substrate of 10 μm width and 3 μm depth parallel microgrooves on the surface could significantly upregulate the expression of anti-inflammatory microRNAs, miR-146a and miR-181b. In addition, the results also showed that TRAF6 and importin-α3, target of miR-146a and miR-181b, respectively, were both down-regulated (P