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has been cited by the following article:

• TITLE: Phenazine Methosulphate Modulating the Expression of Genes Involved in Yeast to Hyphal Form Signal Transduction in Candida albicans

  AUTHORS: Ashwini Khanderao Jadhav, Priyanka Jangid, Rajendra Patil, Wasudev Gade, Kiran Kharat, Sankunny Mohan Karuppayil

  KEYWORDS: Phenazine Methosulphate, Candida albicans Y-H Form Transition, Biofilm, Tup1, Mig1 and Nrg1

  JOURNAL NAME: Advances in Microbiology, Vol.7 No.11, November 10, 2017

  ABSTRACT: Candida albicans has ability to switch from yeast to hyphal form which is an important virulence factor. The objective of the research is to study the effect of Phenazine Methosulphate (PMS) on virulence factors and to study expression profile in yeast to hyphal form transition in C. albicans. Phenazine Methosulphate (PMS) acted as an inhibitor of yeast to hyphal form transition, adhesion and biofilm formation in C. albicans. RTPCR study demonstrated that PMS Modulate the expression of genes involved in Ras1-cAMP-Efg1 and Cek1-MAPK signal transduction pathways. Cell cycle of C. albicans was arrested at S phase on treatment of PMS. Hyphal suppressor genes like Tup1, Mig1 and Nrg1 were upregulated by PMS. Based on our data on expression of genes during yeast to hyphal form transition in presence and absence of PMS, we hypothesize that inhibition of hyphal formation may be due to the overexpression of negative regulators of hyphal growth. Targeting of hyphal specific genes involved in these pathways may be a promising strategy for anti-candida drug development.