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Freeman, M.P., Hirschberg, A.M., Wang, B., Petrillo, L.F., Connors, S., Regan, S., Joffe, H. and Cohen, L.S. (2013) Duloxetine for Major Depressive Disorder and Daytime and Nighttime Hot Flashes Associated with the Menopausal Transition. Maturitas, 75, 4-170.
https://doi.org/10.1016/j.maturitas.2013.03.007

has been cited by the following article:

• TITLE: Trace Determination of Duloxetine HCl in Formulation and Spiked Human Serum at a Carbon Paste Electrode

  AUTHORS: Amira M. Hassanein, Youssef I. Moharram, Naglaa F. Oraiby, Sherif E. Ebied

  KEYWORDS: Square Wave, Linear Sweep, Cyclic Voltammetry, Cymbalta® Tablets, Human Serum

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.8 No.11, November 9, 2017

  ABSTRACT: The electrochemical behavior of duloxetine HCl (DXT.HCl) at a carbon paste electrode (CPE) was achieved by cyclic voltammetry and a mechanism of its oxidation was reported and illustrated. A sensitive linear sweep and square-wave adsorptive anodic stripping voltammetry methods were described for trace determination of DXT.HCl. Introduction: DXT.HCl, N-methyl-3-(nap-thalen-1- yloxy)-3-(thiophene-2-yl) propan-1-amine hydrochloride is a selective serotonin-norepinephrine reuptake inhibitor (SNRI) originally developed as an antidepressant and is currently recommended for maintenance treatment of major depressive disorder. Methods: Electrochemical behavior was studied using cyclic voltammetric method, and the analytical application was studied using linear sweep and square wave voltammetric methods. Solution pH has been measured by pH meter. Results: The process on the surface of carbon paste electrode was found to be irreversible and diffusion-controlled. The number of proton and electron transferred were calculated. Possible reaction mechanism taking place on the surface of electrode was proposed. Calibration plot constructed using square wave voltammetric technique was used for quantitative analysis in pharmaceutical and human serum samples. Limit of detection (LOD) and limit of quantification (LOQ) were calculated. Conclusions: In the present work, we described the electrochemical behavior of DXT.HCl drug. Two precise linear sweep and square wave adsorptive anodic stripping voltammetry methods have been described for its trace quantitation in pharmaceutical formulation and human serum. The method shows the development of a sensor for selective and sensitive determination of DXT.HCl.