Article citationsMore>>
Ren, Z., Gay, R., Thomas, A., Pae, M., Wu, D., Logsdon, L., Mecsas, J. and Meydani, S.N. (2009) Effect of Age on Susceptibility to Salmonella Typhimurium Infection in C57BL/6 Mice. Journal of Medical Microbiology, 58, 1559-1567.
https://doi.org/10.1099/jmm.0.013250-0
has been cited by the following article:
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TITLE:
Age Does Not Affect the Induction of Mortality by the Foodborne Pathogen Salmonella enterica in Caenorhabditis elegans
AUTHORS:
Dawn M. F. Burns, James M. Harper, Aaron M. Lynne
KEYWORDS:
Salmonella enterica, Caenorhabditis elegans, Aging, Infection
JOURNAL NAME:
Advances in Microbiology,
Vol.7 No.10,
October
31,
2017
ABSTRACT: Salmonella is a common cause of foodborne illness within the United States
with the severity of the infection being a factor of both the age and overall
health of the infected individual. The nematode worm Caenorhabditis elegans
has proven to be a useful model to study infection dynamics of pathogenic
bacteria, including Salmonella enterica, and its short lifespan makes it a powerful
model system to assess the effect of organismal age on infection severity.
In this study, we infected C. elegans with each of 6 serovars of S. enterica at
1, 3 or 5 days of worm age and monitored their survival. Worms infected with
E. coli OP50 were used as a control. Infection with S. enterica resulted in a
significant reduction in mean longevity relative to OP50 (p