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Nagata, S., Yamashiro, Y., Ohtsuka, Y., Shimizu, T., Sa-kurai, Y., Misawa, S. and Ito, T. (2009) Heat shock pro-teins and superantigenic properties of bacteria from the gastrointestinal tract of patients with Kawasaki disease. Immunology, 128, 511-520. doi:10.1111/j.1365-2567.2009.03135.x

has been cited by the following article:

• TITLE: Antimicrobial therapy using sulfamethoxazole trimethoprim for Kawasaki disease patients unresponsive to intravenous immunoglobulin

  AUTHORS: Satoru Nagata, Yuichiro Yamashiro, Makoto Fujimori, Yukihide Chiba, Yoshikazu Ohtsuka, Toshiaki Shimizu

  KEYWORDS: Antimicrobial Therapy; Intravenous Immunoglobulin Resistance; Kawasaki Disease; Sulfamethoxazole Trimethoprim

  JOURNAL NAME: Open Journal of Pediatrics, Vol.1 No.3, September 27, 2011

  ABSTRACT: Our previous study suggested that the production of superantigens and heat-shock protein 60 by small intestinal bacteria might play a role in Kawasaki disease (KD). We demonstrated that they were all resistant to commonly used antibiotics, except for sulamethoxazole trimethoprim (SMX-TMP). We used SMX-TMP for 7 cases of KD that were unresponsive to intravenous immunoglobulin (IVIG) and studied the antipyretic potency of this treatment. In 6 out of the 7 cases, we demonstrated that antipyretic potency was observed without side effects within 2 days of the initial administration. Antimicrobial therapy using SMX-TMP might represent a novel strategy for cases of KD that are unresponsive to IVIG.