TITLE:
Synthesis, Characterization and Analysis of Leishmanicide Ability of the Compound [Ru(Cl)3(H2O)2(gly)]
AUTHORS:
Marcio Adriano S. Chagas, Anderson Dourado Galvão, Fabricio Tarso de Moraes, A. T. B. N. Ribeiro, Adriano Buzutti de Siqueira, I. C. C. de Assis Salama, Wagner Welber Arrais-Silva, Katia Meirelles Duarte de Sousa, Claudia Cristina de Sousa Pereira, Wagner Batista dos Santos
KEYWORDS:
Ruthenium, Glycine, Spectroscopy, Infrared TG/DTG and TG/DTA, Amino Acid
JOURNAL NAME:
Open Journal of Inorganic Chemistry,
Vol.7 No.4,
October
26,
2017
ABSTRACT: Studies of coordinated compounds containing ruthenium (Ru2+ and Ru3+) have shown very effective in vitro results for the treatment of cancer and neglected diseases such as leishmaniasis. In this paper, we present the synthesis of the compound [Ru(Cl)3(H2O)2(gly)], which was characterized by spectroscopic (Ultraviolet-visibleand infrared) and thermal analysis (Thermogravimetry/Derived Thermogravimetry and Thermogravimetry/Differential Thermal Analysis). The analysis of the compound in the Ultraviolet-visibleregion showed a 290 nm band λmax (ε= 1.685 × 103 L·cm-1·mol-1), attributed to the ligand metal charge transfer (LMCT). The spectroscopy (IR) showed major vibrational bands at δa (-COO-) 1664 cm-1, δs (-COO-) 1388 cm-1, δs () 1571 cm-1 and δs (CCN) 889 cm-1. The thermal analysis by TG/DTG and TG-DTA indicated that the complex has five consecutive stages of decomposition: at 115°C (TG = 12.18%; Calculated = 11.32%) H2O (coordinating water), exothermic peaks at 230°C, 307°C, 440°C and 463°C due to oxidative decomposition of glycine, followed by the formation of RuClO residue at 665°C (TG = 41.11%; Calculated = 40.81%). The thermal characterization suggested the stoichiometry of the complex [RuCl3(H2O)2(gly)]. The antileishmanial capacity of this compound was also evaluated and the results indicated a 31% decrease in the parasitic infection of macrophages and a 1.5 to 3 fold reduction in the number of parasites per cell after treatment with 100 μg/mL of the complex. These results support the possible use of this compound as a therapeutic alternative against medical and veterinary parasites.