TITLE:
Association of Dyslipidemia and Glycated Haemoglobin in Gestational Diabetes Mellitus
AUTHORS:
M. Lenin, R. Ramesh, V. Kuzhandai Velu, Seetesh Ghose
KEYWORDS:
Gestational Diabetes Mellitus, Lipid Profile, HbA1c
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.7 No.4,
October
26,
2017
ABSTRACT: Background: GDM
is a condition where there is an onset of carbohydrate intolerance during
pregnancy. In this condition many changes will take place in carbohydrate
metabolism and other metabolic pathways especially in lipid metabolism. These
metabolic changes associated with insulin resistance and dyslipidemia. We have
aim to study the association between dyslipidemia and glycated haemoglobin. Materials
and Methods: The study was conducted in 80 pregnant women of rural
population of Puducherry in two groups. Group 1 includes 40 newly diagnosed GDM
patients by DIPSI and Group II with 40 normal pregnant women, age group were
between 20 to 40 years. Fasting blood glucose, 2-hour post glucose and lipid
profile were estimated by auto analyzer. HbA1c was analysis by HPLC method. For
comparisons of means student t-test was used to determine the significance
between GDM and controls. Results: There was statistically significant
difference in lipid profiles (P = 0.05), HDL (P = 0.04), VLDL (P = 0.00), LDL (P = 0.04) HDL (P = 0.04) in GDM groups. HbA1c (P = 0.02)
levels were statistically significant with GDM pregnant women. There was no
statically significant difference between FG (P = 0.23), TG (P = 0.30)
and lipids profiles ratio levels in GDM. Conclusion: This study was
found to be associations between lipids profiles and Gestational diabetes mellitus
in GDM groups.