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Subrahmanyam, S., Ahmed, T., Pinjari, J., Patole, P., Ravindran, S., Gangal, R., Wangikar, P., Basu, S. and Rastogi, H. (2012) Translational Drug Discovery Research: Integration of Medicinal Chemistry, Computational Modeling, Pharmacology, ADME and Toxicology. Encyclopedia of Drug Metabolism and Interactions, Chapter 18, 1-54.

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• TITLE: Purification of Nanoparticles by Liquid Chromatography for Biomedical and Engineering Applications

  AUTHORS: Jitendra K. Suthar, Rutuja Rokade, Ashutosh Pratinidi, Rajeshree Kambadkar, Selvan Ravindran

  KEYWORDS: Nanoparticles, Liquid Chromatography, Purification, UV-Vis Spectroscopy, Nanobiomaterials

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.8 No.10, October 24, 2017

  ABSTRACT: Nanoparticles are extensively used for various applications in science, engineering and medicine. Synthesis of nanoparticles with high purity is essential to utilize the same in different fields of science and technology. In the present study, liquid chromatography is utilized to purify the nanoparticles. Predominantly, gold nanoparticles were synthesized from gold auric cholide and preserved in phosphate or citrate buffer. A method to purify gold nanoparticles is essential because of the possible interference from gold auric chloride and other impurities in buffer. Herein, a method has been developed using high performance liquid chromatography to purify gold nanoparticles with 100 nm in size from gold auric chloride and residues. UV-Vis spectroscopy was also done to ascertain the purity of the nanoparticles.