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Pope, C., Karanth, S. and Liu, J. (2005) Pharmacology and Toxicology of Cholinesterase Inhibitors: Uses and Misuses of a Common Mechanism of Action. Environmental Toxicology and Pharmacology, 19, 433-446.

has been cited by the following article:

• TITLE: Effects of Dimethoate Exposure on Locomotor Activity and Anxiety-Like Behavior in Female Wistar Rat

  AUTHORS: Majda Samih, Pacôme Kouadio N’Go, Sabah Belaaouja, Amina Ouazzani Touhami, Ahmed Omar Touhami Ahami

  KEYWORDS: Acetylcholinesterase Activity, Neurotoxicity, Dimethoate, Neurobehavior, Organophosphate Insecticides

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.7 No.10, October 24, 2017

  ABSTRACT: Developmental exposure to organophosphate insecticide is well known to induce neurobehavioral impairments, at late period. The present study aims to investigate the effects of subchronic exposure to Dimethoate, on locomotors skills and anxiety like behavior among wistar rat. Two groups of female’s rats are used. The intoxicated group receives daily, during five weeks, by intragastric gavage, a dose of Dimethoate dissolved in corn oil (100 mg/kg body weight). The control group receives only the corn oil. Spontaneous locomotors activity is evaluated using the Open Field test (OF) and anxiety-like behavior is measured using Elevated Plus-Maze (EPM). Dimethoate induced significant impairment of spontaneous locomotors activities, which is reflected by high decrease of number of squares crossed (SC) in OF. Females exposed to Dimethoate develop further anxiety-like response, expressed by significant reductions of the time spent in open arm of Elevated Plus-Maze.