TITLE:
Fertility Preservation in Premature Ovarian Insufficiency (POI) Secondary to FSH Receptor Gene (FSHR) Mutation: Is There a New Hope?
AUTHORS:
Pierre-Antoine Pradervand, Roland Antaki, Simon Phillips, C. Sylvestre, Zaki El Haffaf, Ariane Godbout, Isaac Jacques Kadoch, Pierre Lehmann
KEYWORDS:
FSH Receptor Mutation, Fertility Preservation, in Vitro Maturation, AMH, Primary Ovarian Insufficiency
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.6 No.10,
October
23,
2017
ABSTRACT: A 19 years old patient with primary amenorrhea was referred to our center. Based on discrepancy between high follicle stimulating hormone (FSH) level and normal ovarian reserve parameters, follicle stimulating hormone receptor (FSHR) mutation was screened. The patient was homozygous in exon 6 of the FSHR gene for the new variant c.479T > C and predicted to result in an aminoacid substitution p.Ile160Thr. One year later, her anti-müllerian hormone (AMH) level inexplicably decreased. Oocyte vitrification was thus offered for fertility preservation. After 17 days of recombinant follicle stimulating hormone (recFSH) (900 IU daily), no follicular growth was seen and estradiol levels remained low. In vitro maturation (IVM) was then suggested. Ten oocytes were successfully vitrified.