TITLE:
MicroRNA and Its Role in Cardiovascular Disease
AUTHORS:
Suvash Pokhrel, Yin Guotian
KEYWORDS:
MicroRNA, Noncoding RNAs, Cardiovascular Disease
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.7 No.10,
October
19,
2017
ABSTRACT: MicroRNAs play a key role in regulation of gene expression during cardiac development and cardiac remodeling. MicroRNAs that present in bodily fluids maybeuseful for screening, diagnosis or therapeutic implication as a treatment. MicroRNAs are relatively new approach targets for researchers and clinicians in today world.MicroRNAs are small noncoding RNA (ncRNA) having approximately 21 to 25 nucleotides in length, and they mainly act as a transcriptional regulators of gene expression in diverse biological processes such as cellular proliferation, differentiation, tumorigenesis to death and so on. There is no doubt that lethiferous cardiac disease is one of the most common causes of deaths worldwide.MicroRNAs may regulate in several cardiovascular pathologies, not only limited to hypertrophy, heart failure, arrhythmias, hypertension, myocardial infarction, dyslipidemias and congenital heart diseases, but in circulation and bodily fluids are potential novel biomarkers for above mentioned cardiac pathologies. Knowing abnormalities in genetic level, early and accurate detection, effective treatment and prevention is the ideal management of cardiovascular diseases in today’s world.However, every detail of an individual microRNA and their system is huge and beyond the scope of this article. Therefore, in this review we try to cover the overall major aspects of the microRNAs and its role in cardiovascular system.