TITLE:
Interaction between Antihypertensive Therapy Class and Pulse Pressure on Outcomes Following Acute Ischemic Stroke
AUTHORS:
Michael Lavelle, Roy O. Mathew, Jaspreet Arora, Avinash Murthy, Le Du, Batyrjan Bulibek, Mandeep Sidhu, Mikhail Torosoff
KEYWORDS:
Acute Ischemic Stroke, Pulse Pressure, Angiotensin Blockers, Beta Blockers, Outcomes
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.8 No.10,
October
17,
2017
ABSTRACT: Goal: The effect of pulse pressure and interactions with type of antihypertensive therapy on mortality after acute ischemic stroke has not been previously evaluated. Materials and Methods: A retrospective cohort study was conducted to evaluate the independent and interactive effects of pulse pressure and antihypertensive class (specifically angiotensin converting enzyme inhibitor/angiotensin type 1 receptor blocker, or beta blocker) on mortality following acute ischemic stroke. Findings/Conclusions: 343 patients were identified with 49 months of follow-up. Baseline pulse pressure was 64 mmHg and age was 66.5 years. Patients were divided at a pulse pressure of 70. Patients with pulse pressure ≥ 70 were older (p