TITLE:
Radio Pet Therapy of Healthy Wistar Rats with 64CuCl2 Labeled to 64Cu(AcAc)2 Supported in Functionalized TiO2 Nanoparticles
AUTHORS:
Tessy López, Juan C. Manrique-Arias, Paola Ramírez, Pamela Larraza, Francisco Rodríguez Reinoso
KEYWORDS:
PET Therapy, Nanoparticles, Functionalized Titania (F-Tio2), Titanium Acetylacetonate [Cu (AcAc)2], Cu(Acac)2/F-Tio2, PET Lesion Detection, Imaging
JOURNAL NAME:
Journal of Encapsulation and Adsorption Sciences,
Vol.7 No.3,
September
26,
2017
ABSTRACT: In
recent years Copper-64 in the chemical form of copper chloride ([64Cu]CuCl2)
has been identified as a potential agent for PET imaging and radionuclide
therapy. The aim of this research was to determine the
biodistribution and the labeling of radio nanoparticle
with 64CuCl2, the nanoparticles Cu(acac)2/F-TiO2 were mixed with 64CuCl2 (20-37 MBq), then the final solution
was used to injected healthy Wistar rats to probe the absorption of nanoparticle
inside tissue trough
of the groups OH that are formed during the functionalization of the Cu(acac)2/F-TiO2.
The “in vivo” evaluation after realize the images study in micro PET equipment,
uptake of the radio-nanoparticle was observed in the digestive system in
the healthy Wistar rats.