TITLE:
Prognostic Impact of HER/2 Expression on Survival of Preoperatively Treated Children with Wilms Tumor at South Egypt
AUTHORS:
Heba A. Sayed, Abeer Refaiy, Mohammed A. Salem
KEYWORDS:
Wilms Tumor, Her/2, Preoperative Chemotherapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.8 No.9,
September
11,
2017
ABSTRACT: Aim: Wilms tumor (WT) is the most frequent type of pediatric renal tumors.
Her/2 is an oncoprotein, its over-expression revealed to play a very vital role
in the progress and improvement of certain tumors. This study evaluates the
possible role of Her/2 as a prognostic indicator in formerly treated WT. Method: Immunohistochemical expression of Her/2 was studied in paraffin material of 40
WT patients followed SIOP 9 protocol. Patients’ medical records reviewed for
clinical, pathological and outcome data and correlated with HER2 expression.
Additional 15 samples of normal surrounding kidney tissue specimens were
included. Results: Her/2 was often expressed in normal kidney tissue
(renal tubules but not glomeruli) and at variable levels in the three elements
of WT. At a median of 84 months, 70% of
patients are living and under follow-up, surgical stage and pathologic subtypes
were the only two factors significantly affect the outcome of our patients (p = 0.000, p = 0.007 & p =
0.004, p = 0.005 for OS (Overall
survival) and DFS (Disease Free survival) respectively). Her/2 expression was
associated with epithelial differentiation (p Conclusion: while the major progress in studying biology
of WT, stage and pathological subtype continues the
only predictive factors of significant value affecting the outcome of patients
with WT. There was important association between Her/2 expression and
histological differentiation in formerly treated Wilms tumor. Non-conclusive
results regarding influence of Her/2 expression on the result of WT patients were found.