Article citationsMore>>

Primas, N., Verhaeghe, P., Cohen, A., Kieffer, C., et al. (2012) A New Synthetic Route to Original Sulfonamide Derivatives in 2-Trichloromethylquinazoline Series: A Structure-Activity Relationship Study of Antiplasmodial Activity. Molecules, 17, 8105-8117.
https://doi.org/10.3390/molecules17078105

has been cited by the following article:

• TITLE: Novel Route for Synthesis of Thiozolidine-2,4-Dione Derivatives as a Mannich Base

  AUTHORS: Ramakrishna Vellalacheruvu, Ramayanam Sai Leela, L. K. Ravindranath

  KEYWORDS: Imidazole Analogues, Thiozolidine-2, 4-Dione Nucleus, Toluenesulfonylmethyl Isocyanide, Combi-Flash Column Chromatography

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.7 No.3, September 6, 2017

  ABSTRACT: The Mannich base of Thiozolidine-2,4-dione derivatives has come to lime light due to their various pharmacological activities. Thiazolidine-2,4-dione is an extensively explored heterocyclic nucleus for designing of novel agents implicated for a wide variety of pathophysiological conditions, that is, diabetes, diabetic complications, cancer, arthritis, inflammation, microbial infection, and melanoma. In present work, synthesis quinoline attached imidazoline derivative using (3 + 2) cyclo-addition via imine of quinoline and TosMIC. These derivatives were converted to Mannich bases of thiozolidine-2,4-dione using Knoevenagel condensation. The sulfonamide analogues of thiozolidine-2,4-Dione were also synthesized and characterized by using alkylation conditions.