TITLE:
Toxicity and Viral Load in Urine during Valganciclovir Therapy in Premature Infants
AUTHORS:
Merel Boesveld, Henrica L. M. Van Straaten, Marieke A. C. Hemels
KEYWORDS:
CMV, Premature Infants, Valganciclovir, Treatment
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.8 No.8,
August
30,
2017
ABSTRACT: Cytomegalovirus (CMV) infection is the most important cause of mental retardation and sensorineural hearing loss. Antiviral treatment with valganciclovir, a relatively new but potential toxic oral drug, is recommended to prevent further hearing deterioration. In this retrospective cohort study we evaluated the relation between the dose of valganciclovir and the reduction of CMV viral load, as well as the toxicity. All neonates with gestational age