TITLE:
Isoniazid-Induced Facial Tics in a Patient on Hemodialysis
AUTHORS:
Yuanwei Wang, Xiaodong Chen, Xiaomei Li, Baolin Zhu, Daoming Tong
KEYWORDS:
Tic, Isoniazid, Tuberculosis, ESRD, Hemodialysis
JOURNAL NAME:
Neuroscience and Medicine,
Vol.8 No.3,
August
24,
2017
ABSTRACT: We report isoniazid (INH) induced tics in one male patient on hemodialysis at end-stage renal failure. He had pulmonary tuberculosis, accepted isoniazid, rifampin, ethambutol, pyrazinamide and rifampicin. He developed tics on both sides of the face. Surprisingly, he was also found the bilateral symmetrical frontal lobe and dentate nucleus hyperintensities on T2-weighted and T2 FLAIR MR imaging. After excluding other causes, INH induced neurological side effect was suspected so the drug was stopped, pyridoxine was added and hemoperfusion was applicated. Tics disappeared after 1 week.