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Odeh, F., Ismail, S.I., Abu-Dahab, R., Mahmoud, I.S. and Al Bawab, A. (2012) Thymoquinone in Liposomes: A Study of Loading Efficiency and Biological Activity towards Breast Cancer. Drug Delivery, 19, 371-377. https://doi.org/10.3109/10717544.2012.727500

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• TITLE: Physicochemical Properties and Control Release of Aloe Vera (Aloe barbadensis Miller) Bioactive Loaded Poly (Lactic Co-Glycolide Acid) Synthesized Nanoparticles

  AUTHORS: Lamin S. Kassama, Jawadul Misir

  KEYWORDS: Nanoencapsulation, PLGA, Aloe Vera Gel, Size Distribution, Time Release Kinetics & Antioxidant

  JOURNAL NAME: Advances in Chemical Engineering and Science, Vol.7 No.4, August 15, 2017

  ABSTRACT: Nano-encapsulation is a platform which offers a promising application for control release and the delivery of drugs in pharmaceuticals and antioxidant/ antimicrobial in food systems. Poly (lactic-co-glycolide acid) (PLGA) is a biodegradable and biocompatible co-polymer of lactic acid and glycolic acid which is used for synthesizing food based polymeric nanoparticles (NP). The aim of this study was to evaluate the morphological and physicochemical properties and the controlled release of bioactive components derived from Aloe vera gel loaded PLGA NP. The results shows the mean hydrodynamic diameter of the unloaded NP is 103 nm which is significantly (p p > 0.05) inhibition of the antioxidant potential was observed with loaded NP. The entrapment efficiency for the FDG synthesized was 87%, and the burst effect was observed after 4 h as a result of the encapsulation effect. The release kinetics of bioactive is govern by the combination of mass diffusion and capillary action.