TITLE:
The Comparison of Area under the Curve of Serum Estradiol during Controlled Ovarian Stimulation between Long Gonadotrophin Releasing Hormone Agonist Protocol and Short Gonadotrophin Antagonist Protocol in Invitro Fertilization
AUTHORS:
Hartanto Bayuaji, Wiryawan Permadi, Herri S. Sastramihardja, Heda Melinda Nazaruddin Nataprawira
KEYWORDS:
Area under the Curve, Controlled Ovarian Stimulation, Estradiol, Long Agonist Protocol, Short Antagonist Protocol
JOURNAL NAME:
Open Access Library Journal,
Vol.4 No.8,
August
7,
2017
ABSTRACT: Background: during stimulation, estradiol levels represent the dynamic hormonal interaction of follicle development. Some studies have been done to evaluate the influence of day-hCG estradiol assay and IVF outcome. However, this assay does not reflect the total exposure of estradiol throughout stimulation. Hence the concept of calculating the area under the curve (AUC) of estradiol during ovarian stimulation is thought to be a better parameter to evaluate total exposure of estradiol to the entire process of IVF. Methods: a retrospective analysis of data from a fertility center in a tertiary hospital. Between 2011-2016, there were long GnRH agonist cycles and short GnRH antagonist cycles eligible for analysis. Data including subject’s characteristics, the level of estradiol on day-2, day-6, and day-hCG during controlled ovarian stimulation were obtained. Those data were plotted, and area under the curve of each subject was calculated. Statistical analysis was done using student t-test while p