TITLE:
Low-Dose Misoprostol versus Vaginal-Insert Dinoprostone for At-Term Labor Induction: A Prospective Cohort Study
AUTHORS:
Laura Emilia Muñoz Saá, María Dolores Martín Ríos, María Rosario Noguero Meseguer
KEYWORDS:
Labor Induction, Cervical Ripening, Misoprostol, Dinoprostone
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.7 No.8,
August
2,
2017
ABSTRACT: Introduction: Given the pharmacological change taking place in Spanish delivery
rooms, we designed this study to compare the effectiveness and safety of
misoprostol (25 mcg/4h) to 10 mg dinoprostone in its slow-releasing vaginalinsert
form to induce at-term labor. Methods: In a prospective cohort study
(2013-2015), 401 at-term pregnant women referred for induction (Bishop
score ≤ 6), who gave birth at the Rey Juan Carlos Hospital in Móstoles (Madrid,
Spain), of whom 241 participants were induced with misoprostol and
160 with dinoprostone. Patients were recruited by non-probabilistic sampling
of consecutive cases as the inductions in the Obstetrics Block during the study
period were indicated. Results: The cesarean section rate was 14% for the misoprostol
group and 19% for the dinoprostone group [RR = 1.38 (95%CI: 0.89
- 2.13), p = 0.145]. No differences were found in the vaginal birth rate in