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Ralser, M., Albrecht, M., Nonhoff, U., Lengauer, T., Lehrach, H. and Krobitsch, S. (2005) An Integrative Approach to Gain Insights into the Cellular Function of Human Ataxin-2. Journal of Molecular Biology, 346, 203-214.

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• TITLE: The Potential of Targeting DNA Repair Deficiency in Acute Myeloid Leukemia

  AUTHORS: Clare M. Crean, Ken I. Mills, Kienan I. Savage

  KEYWORDS: DNA Repair, Acute Myeloid Leukemia

  JOURNAL NAME: Journal of Cancer Therapy, Vol.8 No.8, July 28, 2017

  ABSTRACT: Acute myeloid leukemia (AML) is a clonal heterogeneous disease of the myeloid white blood cells. It is characterised by an accumulation of immature blast cells and a number of chromosomal and genetic mutations have been identified. In both de novo and therapy-related AML, defective DNA repair mechanisms are responsible for some of these genetic abnormalities. Targeting the DNA repair mechanism has been shown to be successful against certain forms of solid tumors and may represent a novel therapeutic approach for AML.