TITLE:
The Potential of Targeting DNA Repair Deficiency in Acute Myeloid Leukemia
AUTHORS:
Clare M. Crean, Ken I. Mills, Kienan I. Savage
KEYWORDS:
DNA Repair, Acute Myeloid Leukemia
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.8 No.8,
July
28,
2017
ABSTRACT: Acute
myeloid leukemia (AML) is a clonal heterogeneous disease of the myeloid white
blood cells. It is characterised by an accumulation of immature blast cells and
a number of chromosomal and genetic mutations have been identified. In both de novo and therapy-related AML,
defective DNA repair mechanisms are responsible for some of these genetic
abnormalities. Targeting the DNA repair mechanism has been shown to be
successful against certain forms of solid tumors and may represent a novel
therapeutic approach for AML.