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Mbah, J.A., Ayimele, G.A., Eyonganyo, E.N. and Nfor, E.N. (2017) Synthesis, Molecular Structure and Antibacterial Activity of Benzylmethyl-4-Methyl-3-Thiosemi-Carbazone. International Journal of Organic Chemistry, 7, 83-90.
https://doi.org/10.4236/ijoc.2017.72007

has been cited by the following article:

• TITLE: Synthesis, Molecular Structure and Antibacterial Activity of 1-(4-Methoxybenzaldehyde)-4-Methylthiosemicarbazone

  AUTHORS: James Ajeck Mbah, Godfred Aponglen Ayimele, Norbert Kodjio, Joseph Ngwain Yong, Emmanuel Ngwang Nfor, Donatien Gatsing

  KEYWORDS: Novel Schiff Base, Antibacterial Activity, Crystal Structure

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.7 No.3, July 27, 2017

  ABSTRACT: A novel ligand, 1-(4-methoxybenzylidene)-4-methylthiosemicarbazone (MBT) derived from 4-methoxybenzaldehyde was synthesized and characterized by spectroscopic methods (IR, 1H NMR, 13C NMR), single crystal X-ray diffraction technique and physical means. MBT showed antibacterial activity in vitro with MICs of 64 μg/mL (a strain of Salmonella typhi (ATCC 6539)), 128 μg/mL (Salmonella typhi), 64 μg/mL (Salmonella paratyphi A), 128 μg/mL (Salmonella paratyphi B) and 64 μg/mL (Salmonella typhimurium). The results showed that MBT demonstrated moderate in vitro antibacterial activity against a strain of Salmonella typhi (ATCC 6539), Salmonella paratyphi A, and Salmonella typhimurium, indicating its promise as a possible lead for the discovery of antibacterial drugs.