TITLE:
Synthesis, Molecular Structure and Antibacterial Activity of 1-(4-Methoxybenzaldehyde)-4-Methylthiosemicarbazone
AUTHORS:
James Ajeck Mbah, Godfred Aponglen Ayimele, Norbert Kodjio, Joseph Ngwain Yong, Emmanuel Ngwang Nfor, Donatien Gatsing
KEYWORDS:
Novel Schiff Base, Antibacterial Activity, Crystal Structure
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.7 No.3,
July
27,
2017
ABSTRACT: A novel ligand,
1-(4-methoxybenzylidene)-4-methylthiosemicarbazone (MBT) derived from 4-methoxybenzaldehyde was synthesized
and characterized by spectroscopic methods (IR, 1H NMR, 13C
NMR), single crystal X-ray diffraction technique and physical means. MBT showed
antibacterial activity in vitro with
MICs of 64 μg/mL (a strain of Salmonella typhi (ATCC 6539)), 128 μg/mL (Salmonella typhi), 64 μg/mL (Salmonella
paratyphi A), 128 μg/mL (Salmonella
paratyphi B) and 64 μg/mL (Salmonella typhimurium). The results showed that MBT demonstrated
moderate in vitro antibacterial
activity against a strain of Salmonella typhi (ATCC
6539), Salmonella paratyphi A, and Salmonella typhimurium,
indicating its promise as a possible lead for the discovery of antibacterial
drugs.