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Fahlbusch, K.-G., Franz-Josef, H., Panten, J., Pickenhagen, W., Schatkowski, D., Kurt, B., Garbe, D. and Surburg, H. (2003) Flavors and Fragrances in Ullmann’s Encyclopedia of Industrial Chemistry. Wiley-VCH, Weinheim.

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• TITLE: Synthesis, Molecular Structure and Antibacterial Activity of 1-(4-Methoxybenzaldehyde)-4-Methylthiosemicarbazone

  AUTHORS: James Ajeck Mbah, Godfred Aponglen Ayimele, Norbert Kodjio, Joseph Ngwain Yong, Emmanuel Ngwang Nfor, Donatien Gatsing

  KEYWORDS: Novel Schiff Base, Antibacterial Activity, Crystal Structure

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.7 No.3, July 27, 2017

  ABSTRACT: A novel ligand, 1-(4-methoxybenzylidene)-4-methylthiosemicarbazone (MBT) derived from 4-methoxybenzaldehyde was synthesized and characterized by spectroscopic methods (IR, 1H NMR, 13C NMR), single crystal X-ray diffraction technique and physical means. MBT showed antibacterial activity in vitro with MICs of 64 μg/mL (a strain of Salmonella typhi (ATCC 6539)), 128 μg/mL (Salmonella typhi), 64 μg/mL (Salmonella paratyphi A), 128 μg/mL (Salmonella paratyphi B) and 64 μg/mL (Salmonella typhimurium). The results showed that MBT demonstrated moderate in vitro antibacterial activity against a strain of Salmonella typhi (ATCC 6539), Salmonella paratyphi A, and Salmonella typhimurium, indicating its promise as a possible lead for the discovery of antibacterial drugs.