Article citationsMore>>

Abedel-Hahez, A.A. and Abdel-Wahab, B.A. (2008) 5-(4-Chlorophenyl)-5,6-dihy-dro-1,3-oxazepin-7(4H)-one Derivatives as Lipophilic Cyclic Analogues of Baclofen: Design, Synthesis, and Neuropharmacological Evaluation. Bioorganic & Medicinal Chemistry, 16, 7983-7991.
https://doi.org/10.1016/j.bmc.2008.07.064

has been cited by the following article:

• TITLE: Synthesis of 1,3-Oxazepine Derivatives Derived from 2-(1H-Benzo[d][1,2,3]Triazol-1-yl) Acetohydrazide by Using Microwave Irradiation

  AUTHORS: Nihad Ismail Taha

  KEYWORDS: Hydrazone, Microwave, Oxezapine, Benzotriazole, Hydrazine

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.7 No.3, July 21, 2017

  ABSTRACT: A series of Schiff base and their derivative (oxazepine) have been synthesized. 8-hydrazone(schiff-bases) derivatives type (E)-2-(1H-benzo[d][1,2,3]triazole-1-yl)-N-(substituted benzylidene)aceto-hydrazide were prepared by condensation 1H-benzo[d][1,2,3]triazol-1-yl)hydrazine with various aromatic aldehyde in ethanol in the presence of dimethyl formamid or acetic acid as catalyst by using MWI to yield the Schiff bases. These Schiff’s base on treatment with Maleic anhydride in dry conditions by using MWI to give 7-membered heterocyclic ring system (oxezapine) of (2-(1H)benzo[d][1,2,3]triazol-1-yl)-N-(2-(substituted penyl)-4, 7-dioxo-4,7-dihydro-1,3-oxazepin-3-(2H)-yl)acetamide. The purity of the compounds was confirmed by TLC. The final products were identified by their melting point, IR, 1HNMR, and UV-visible spectra.