TITLE:
Seroprevalence Virus in Human Immunodeficiency Sickle Cell Anemia Duffy-46C/C in Democratic Republic of Congo—Case of the City of Kinshasa and Lubumbashi
AUTHORS:
P. Lungu Anzwal, A. Kambote Kalumba, J. Kasali Mwamba, Saragosti S. Sentob, H. Situakibanza Nani Tuma, Ekwalanga M. Balaka
KEYWORDS:
HIV, Sickle Cell Anemia Duffy-46C/C, Blood Transfusion
JOURNAL NAME:
Open Access Library Journal,
Vol.4 No.7,
July
20,
2017
ABSTRACT: Homozygous sickle cell disease undergoes multiple blood transfusions during their life because of chronic hemolytic anemia associated with their condition and the risk of infection is most convincing, for example vis-à-vis certain viruses such as HIV, the virus hepatitis. This study aims to determine the HIV seroprevalence among sickle cell anemia Duffy-46C/C. This is a cross-sectional descriptive study to determine HIV seroprevalence in Duffy-46C/C sickle-cell anemia, conducted at the Yolo Sud SS Joint Medical Center in St. Crispin in Kinshasa and Jason Sendwe Hospital in Lubumbashi, from 2015 to 2016. HIV seroprevalence of 505 subjects homozygous sickle cell Duffy-46C/C was established by Immuno-chromatography tests determined HIV1/2 test Uni-Gold to determine the anti-HIV antibodies. CD4 rate was also determined and plasma viral load. We collected 505 samples of blood from sickle cell anemia aged from 1 year to 65 years (mean age 15.6 years) with 235 subjects male and 270 female subjects. A positive serology was found in 6 cases (1.19%), including 5 female subjects of which 4 cases had received 1-5 transfusions and 2 cases were vaso-occlusive crisis (VOC). Viral load was determined, and 4 individuals were detectable and 2 were undetectable. Their CD4 levels were raised to more than 500 c/μL, ranging between 543 to 893 c/μl. The blood transfusion remains a risk in the transmission of HIV/AIDS among people polytransfusees, due probably to the window door. We will have to strengthen blood safety by equipping laboratories and blood banks with reliable early tests that detect viral RNA of HIV.