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Johnson, R.R., Wong, J.H., Awad, I.A., Kim, J.H., Bolognia, J.L. and Sawaya, R. (1999) Hemorrhagic Lesion at the Tentorial Incisura in a Patient with Facial Nevus. Neurosurgery, 45, 1216-1221.

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• TITLE: Intracranial Intermediate-Grade Melanocytic Neoplasm: Case Report Associated with Nevus of Ota

  AUTHORS: Dorothy Sze Wing Hung, Calvin Hoi Kwan Mak, Fung Ching Cheung

  KEYWORDS: Melanocytic Neoplasm, Leptomeninges, Nevus of Ota

  JOURNAL NAME: Open Journal of Modern Neurosurgery, Vol.7 No.3, July 5, 2017

  ABSTRACT: Melanocytic lesions of the CNS are rare tumours originating from melanocytes that are present in the leptomeninges. They consist of a spectrum of pigmented tumours ranging from melanocytoma to melanoma. A small group of these tumours have histopathological features between those of a benign melanocytoma and a malignant melanoma; these present as intermediate grade melanocytic neoplasms. Naevus of Ota is a blue hyperpigmented dermal lesion characterized by increased number of melanocytes in the distribution of ophthalmic and maxillary divisions of the trigeminal nerve. The association of an intracranial intermediate-grade melanocytic neoplasm with a nevus of Ota is extremely rare, with only 2 cases reported in the literature to date. As a result, their behavior and progression are still poorly understood. We present the first case of a familial naevus of Ota associated with intermediate-grade melanocytic neoplasm.