TITLE:
A Case of Exfoliation of Oral Mucosal Epithelium in a Patient with Anti-Desmoglein 1 Antibody-Positive and Anti-Desmoglein 3 Equivocal Antibody
AUTHORS:
Michiko Ozawa, Yoshinori Jinbu, Hiromi Hayashi, Tadahide Noguchi, Yoshiyuki Mori
KEYWORDS:
Anti-Desmoglein 3 Antibodies, Anti-Desmoglein 1 Antibodies, Autoimmune Bullous Disease, Oral Mucosa
JOURNAL NAME:
Open Journal of Stomatology,
Vol.7 No.6,
June
29,
2017
ABSTRACT: Pemphigus is an autoimmune bullous disease observed with lesions in the skin and mucosa. Pemphigus is classified by antibodies against desmogleins, which is cadherin type intercellular adhesion factors involved in adhesion between epidermal cells. In this case, because erosion of the oral mucosa was the primary symptom, a relationship with membrane-dominant pemphigus vulgaris was strongly suspected. And in terms of histopathology, findings not conflicted with pemphigus vulgaris were observed, but given all these different findings, the results did not correspond with bullous pemphigoid in clinical findings, and with pemphigus foliaceus and pemphigus vulgaris in various testing results, leading us to believe this represented a very rare case. We started oral health care, and when application of steroid ointment to the entire surface of the mucosa was continued, symptoms disappeared within approximately 2 months. In this case, relapse has not yet occurred and periodic follow-up was continued.