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Masaki, Y., Kumano, K., Iwamura, M., Endo, T., Sakai, T., Koshiba, K., Nakamura, K., Yokota, K., Sato, K., Uchida, H. and Aso, K. (1989) Protective Effect of an Organic Germanium Compound on Warm Ischemia and Prolonged Kidney Preservation. Transplantation Proceedings, 21, 1250-1251.

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• TITLE: Organogermanium (Ge-132) Suppresses Activities of Stress Enzymes Responsible for Active Oxygen Species in Monkey Liver Preparation

  AUTHORS: Takafumi Tezuka, Atsunori Higashino, Mitsuo Akiba, Takashi Nakamura

  KEYWORDS: Active Oxygen Species, Stress Enzymes [CAT, NAD(P)H-OD, SOD, XOD], Ge-132 [(GeCH2CH2COOH)2O3]n, Monkey Liver

  JOURNAL NAME: Advances in Enzyme Research, Vol.5 No.2, June 2, 2017

  ABSTRACT: Assays of stress enzymes related to active oxygen species were performed by using an in vitro preparation from the liver of a monkey (Japanese Macaque). Ge-132, an organic germanium compound, viz. poly-trans-[(2-carboxyethyl) germasesquioxane] [(GeCH2CH2COOH)2O3]n, suppressed the activities of NADH-dependent oxidase and NADPH-dependent oxidase [NAD(P)H-OD] and xanthine oxidase (XOD) as superoxide-forming enzymes, while promoting the activities of superoxide dismutase (SOD) as a superoxide-scavenging enzyme and catalase (CAT) as an enzyme responsible for degradation of hydrogen peroxide (H2O2). The evidence suggests that the levels of active oxygen species such as and H2O2 would be reduced by Ge-132. The possible connection between Ge-132 and activities of stress enzymes is discussed on the basis of these results.