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Carvalho, B.M.A., Santos, J.D.L., Xavier, B.M., Almeida, J.R., Resende, L.M., Martins, W., Marcussi, S., Marangoni, S., Stábeli, R.G. and Calderon, L.A. (2013) Snake Venom PLA2s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules. BioMed Research International, 2013, Article ID: 15304.

has been cited by the following article:

• TITLE: Essential Oils from Mentha viridis (L). L. and Mentha pulegium L.: Cytogenotoxic Effects on Human Cells

  AUTHORS: Lucilene Fernandes Silva, Maria das Graças Cardoso, Paulo Sérgio Castilho Preté, Maria Luisa Teixeira, David Lee Nelson, Maísa Lamounier Magalhães, Vanuzia Rodrigues Fernandes Ferreira, Rafaela Vieira Souza, Luana Isac Soares, Silvana Marcussi

  KEYWORDS: Essential Oils, Mentha viridis (L). L., Mentha pulegium L., Hemolysis, Comet Assay

  JOURNAL NAME: American Journal of Plant Sciences, Vol.8 No.6, May 26, 2017

  ABSTRACT: The essential oils from Mentha viridis (L). L. and Mentha pulegium L. were studied to assess their inhibitory potential on phospholipase from snake venoms and to determine their cytogenotoxic action on human cells. These essential oils were able to inhibit the breakdown of phospholipids induced by venoms of snakes of the Bothrops genus. Both oils presented hemolytic activity, although the Mentha viridis (L). L. oil induced hemolysis only at the highest concentrations (14.6 and 29 μL·mL-1). The essential oil from M. viridis induced 3.9; 8.6 and 16.2 times greater damage to human leukocyte DNA than that observed with the positive control (100 μg·μL-1 doxorubicin) at concentrations of 0.25; 0.5 and 1.0 μL·mL-1, respectively. A similar effect was observed for the oil from M. pulegium (2.1, 2.5 and 15.8 times greater damage). The results extend the characterization of these essential oils and demonstrate their potential use in industries.