TITLE:
Analysis of a Questionnaire Survey regarding Current Conditions against Exposure to Anticancer Drugs and Reports of Cancer Chemotherapy at Outpatient Departments in Japan
AUTHORS:
Tsuyoshi Shirakawa, Tomoko Hara, Kojiro Hata, Kojiro Hata, Kimitaka Suetsugu, Hideki Kakimoto, Kentaro Ogata, Yousuke Ikari, Hidenori Sasaki, Makoto Takahashi, Masaru Fukahori, Miyuki Uoi, Taito Esaki, Mikako Hiraike, Toshinobu Hayashi, Akira Tokunaga, Norio Ureshino, Tsuneo Kuwamura, Hitoshi Kusaba, Kenji Mitsugi, Eishi Baba
KEYWORDS:
Exposure, Anticancer Drugs, Measurement, Personal Protective Equipment, Outpatient Service
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.8 No.5,
May
22,
2017
ABSTRACT: [Background] Medical staff have many occasions to be exposed to anticancer drugs (ACDs) in the process of performing cancer chemotherapy. Although guidelines for the safe handling of ACDs have been published, actual measures against exposure to ACDs differ between hospitals, and no surveillance data regarding the conditions of each hospital in relation to performing chemotherapy in Japan are available. [Methods] To understand current measures against exposure to ACDs and problems related to cancer chemotherapy at outpatient departments, we conducted a questionnaire survey on doctors, pharmacists, and nurses in 10 leading hospitals for cancer chemotherapy in Japan. [Results] Responses were received from all 10 institutions. The hospital pharmacists prepared all ACDs for outpatients in each institution. All hospitals took basic measures against ACD exposure, such as using personal protective equipment and penetration-resistant waste containers. Conditions against exposure to ACDs generally improved between 2012 and 2015, especially in terms of conveyance of ACDs and use of a closed-system drug transfer device. However, no measures linking ACDs with administration routes or injection sites were commonly taken in any of the hospitals in 2015. [Conclusions] Conditions against ACD exposure improved between 2012 and 2015, possibly because new guidelines were issued. To improve measures for ACD exposure in Japan, preparing more appropriate manuals and offering more opportunities to medical staff for continuing education are considered important.