TITLE:
Giant Cell Tumour of the Skull Base Treated with Surgery, Stereotactic Radiosurgery and Denosumab: Case Report and Review of Literature
AUTHORS:
Jorge H. Guajardo, Cuauhtemoc de la Peña, Maria F. Gonzalez, Cesar Gonzalez, Carlos Cuilty, Horacio Decanini
KEYWORDS:
Giant Cell Tumour, Skull Base, Stereotactic Radiosurgery, Denosumab
JOURNAL NAME:
Open Access Library Journal,
Vol.4 No.5,
May
16,
2017
ABSTRACT: Giant
cell tumours (GCT) of the skull base account for approximately 1% of all GTC of
the bone. Despite being considered as a benign neoplasm, they are locally aggressive with high recurrence rates after incomplete
surgery. Due to the small number of cases reported in skull base, standardized treatment remains unclear. Even with new surgical
techniques, a complete resection in skull base tumours is not
always possible without functional compromise. Therefore, adjuvant therapy is
essential to enhance local control and quality of life. We described a case
treated successfully with primary surgery followed by Cyberknife stereotactic radiosurgery (SRS) and denosumab with a 48-month follow-up.
To the best of our knowledge, the usage of combined therapy, SRS and
denosumab, in skull base GCT has not been previously described.