TITLE:
The Uses of 2-Amino-4-Phenylthiazole in the Synthesis of Coumarin, Pyran, Pyridine and Thiazole Derivatives with Antitumor Activities
AUTHORS:
Faten I. Hamed, Abeer A. Mohamed, Amr S. Abouzied
KEYWORDS:
Thiazole, Pyran, Pyridine, Antitumor
JOURNAL NAME:
Open Access Library Journal,
Vol.4 No.5,
May
4,
2017
ABSTRACT: The thiazole derivative 3
was used for a series of heterocyclization reaction to produce pyran, pyridine
and thiazole derivatives. The cytotoxicity of the newly synthesized compounds
was studied against the six cancer cell lines namely NUGC, HR, DLD1, HA22T, HEPG2, MCF, HONE1 and
normal fibroblast cells (WI38). The results showed that most of the synthesized
compounds were of high potency. Among the tested compounds, 2-Amino-4-(4-chlorophenyl)-6-(4-phenylthiazol-2-yl)-4H-pyran-3,5-dicarbonitrile 17b showed the highest
potency among the tested compounds.