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Naziroglu, M., Kuraoglu, A. and Aksoy,A. 2004. Sele-nium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal and lens tissue in rat. Toxicology, 195, 221-230. doi:10.1016/j.tox.2003.10.012

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• TITLE: The role of vitamin C in alteration of enzymes responsible of energy metabolism induced by administration of tamoxifen to mouse

  AUTHORS: Zaina Zuhair, Hasan AL-amri

  KEYWORDS: Adult Male Albino Mice; Tamoxifen Vitamin C; Liver Tissue Homogenates

  JOURNAL NAME: Advances in Biological Chemistry, Vol.1 No.2, August 22, 2011

  ABSTRACT: Tamoxifen is a synthetic non-steroidal ant estrogen. It was suggested to study the role of vitamin C in alte- ration of enzymes responsible of energy metabolism induced by administration of tamoxifen to mouse. The effect of tamoxifen and tamoxifen with vitamin C on some activity of enzymes in the mice representing gly- colytic, gluconeogenic and glycogenolytic pathway and also, liver function enzymes represented by aspartate aminotransferase (AST), alanine amino-transferase (ALT), acid phosphatase (ACP) and alkaline phos- phatase (ALP) were studied. The present results showed that a significant (p