TITLE:
JAK-STAT Lodges in Multiple Sclerosis: Pathophysiology and Therapeutic Approach Overview
AUTHORS:
Kabir Magaji Hamid, Abdullahi Isiyaku, Mustapha Umar Kalgo, Isah Suleiman Yahaya, Abbas Mirshafiey
KEYWORDS:
Cytokines, Janus Kinases, Multiple Sclerosis, Neurogenesis, Signal Transduction, Transcription Factors
JOURNAL NAME:
Open Access Library Journal,
Vol.4 No.4,
April
27,
2017
ABSTRACT: Multiple sclerosis (MS) is
a complex inflammatory and demyelinating disease of central nervous system
(CNS). The disease pathogenesis is not fully understood and no actual cure for
the disease yet. The disease has genetic and environmental cause as fundamental
factors which are identified for the disease pathogenesis so far. One of the characteristic
features of the disease is inflammation cause due to activation of pro-inflammatory
cells. Interference in signalling pathways such as JAK/STAT could result in
physiological or pathological outcome in MS. Dysregulation of JAK/STAT
signalling pathway is associated with chronic inflammatory process and immune
disorders. In this review, considering the important role of JAK/STAT pathway
in signal transduction of inflammatory process and immune responses in CNS, we describe the involvement of this signal transduction pathway in MS. Moreover,
we consider the physiological and pathological involvement of JAK/STAT rout in neurogenesis/gliogenesis,
cytokines production and as therapeutics target for managing MS.