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Kumar, Y.R., Babu, J.M., Sarma, M.S.P., Seshidhar, B., Reddy, S.S., Reddy, G.S. and Vyas, K. (2003) Application of LC-MS/MS for the Identification of a Polar Impurity in Mosapride, a Gastroprokinetic Drug. Journal of Pharmaceutical and Biomedical Analysis, 32, 361-368. https://doi.org/10.1016/S0731-7085(03)00076-1

has been cited by the following article:

• TITLE: Prediction of the Fragmentation Pathway of Atorvastatin by Using High Resolution Collision Induced Dissociation (HR-MS/MS) Spectral Information

  AUTHORS: Dev Kant Shandilya, Rekha Israni, Peter Edward Joseph, Venkata Siva Satyanarayana Kantamreddi

  KEYWORDS: Atorvastatin, Small Drug Molecules, High Resolution Mass Spectrometry, Fragmentation, Rational Workflow, Interpretation

  JOURNAL NAME: Open Access Library Journal, Vol.4 No.3, March 30, 2017

  ABSTRACT: Introduction: A possible fragmentation pathway of atorvastatin was proposed based on rational interpretation of high resolution collision induced dissociation (CID) fragmentation spectral data. Method: The mass spectral (MS and MS/MS) data of atorvastatin was obtained by using a flow injection analysis, LC coupled with high resolution mass analyzer system with Q-TOF technology. Results: The elemental composition for each major fragment was proposed with a calculated mass error in parts per million (ppm). The mass error found in this study is from 0.3 to 5.7 ppm; strongly supports all the proposed elemental composition of fragments. Based on the fragments, possible fragmentation pathway was proposed. Conclusion: The workflow followed for interpretation can also address the structural possibilities of similar type of small organic molecules.